The Malignant Hypertension-Thrombotic Microangiopathy Link

The malignant hypertension-thrombotic microangiopathy link.

Acute renal failure secondary to malignant hypertension induced thrombotic microangiopathy.

T thrombotic microangiopathy (TMA) represents a discreet group of disorders with common pathological features including fibrinoid necrosis, endothelial cell injury, and obstruction of vessels.1 The clinical presentation of TMA includes microangiopathic hemolytic anemia, thrombocytopenia, and functional impairment of various organ systems. Hemolytic uremic syndrome (HUS) and thrombotic thrombocy...

Pulmonary tumour thrombotic microangiopathy: unclassifiable pulmonary hypertension?

References 1 Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2013; 62: D34–D41. 2 Gurtner HP. Aminorex and pulmonary hypertension. A review. Cor Vasa 1985; 27: 160–171. 3 Kay JM, Smith P, Heath D. Aminorex and the pulmonary circulation. Thorax 1971; 26: 262–270. 4 Simonneau G, Fartoukh M, Sitbon O, et al. Primary pulmonary...

Pulmonary tumour thrombotic microangiopathy: unclassifiable pulmonary hypertension?

Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressure ⩾25 mmHg, and can be associated with multiple conditions. The diagnostic strategy and treatment of PH is heavily reliant on accurately classifying patients [1]. We recently identified two patients presenting with rapidly fatal PH of unknown aetiology, who were subsequently diagnosed at post mortem with pulmonary tumour t...

A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension

BACKGROUND Lipoprotein glomerulopathy (LPG) is a rare inherited renal disease characterized by intraglomerular lipoprotein within the lumina of severely dilated glomerular capillaries. The common clinical presentation of LPG includes proteinuria or nephrotic syndrome. Hypertension and anemia were thought to be mild in LPG. Thrombotic microangiopathy (TMA) in LPG has not been previously reported...